Scientists reveal molecular 'turbo' switch in the brain that could allow us to store more information and boost our brainpower
- Brain function and memory recall is improved when molecule is removed
- Could eventually be used to adjust memory formation and retrieval
- Breakthrough could help treat autism spectral disorders and Alzheimer's
Scientists have revealed a switch in the brain that could be used to give it a turbo boost, allowing us to store more information and improve memory.
Researcher have identified a molecule that puts a brake on brain processing, and found when it was removed, brain function and memory recall is improved.
They hope the discovery could have implications for neurodevelopmental and neurodegenerative diseases, such as autism spectral disorders and Alzheimer's disease.
A protein, FXR1P (Fragile X Related Protein 1), was responsible for suppressing the production of molecules required for building new memories – and when removed, brainpower was boosted.
WHAT THEY FOUND
Dr. Murai and his colleagues used a mouse model to study how changes in brain cell connections produce new memories.
They demonstrated that a protein, FXR1P (Fragile X Related Protein 1), was responsible for suppressing the production of molecules required for building new memories.
When FXR1P was selectively removed from certain parts of the brain, these new molecules were produced that strengthened connections between brain cells and this correlated with improved memory and recall in the mice.
'Previous research has shown that production of new molecules is necessary for storing memories in the brain; if you block the production of these molecules, new memory formation does not take place,' said Dr. Keith Murai of the Research Institute of the McGill University Health Centre.
'Our findings show that the brain has a key protein that limits the production of molecules necessary for memory formation.
'When this brake-protein is suppressed, the brain is able to store more information.'
Dr. Murai and his colleagues used a mouse model to study how changes in brain cell connections produce new memories.
They demonstrated that a protein, FXR1P (Fragile X Related Protein 1), was responsible for suppressing the production of molecules required for building new memories.
When FXR1P was selectively removed from certain parts of the brain, these new molecules were produced that strengthened connections between brain cells and this correlated with improved memory and recall in the mice.
'The role of FXR1P was a surprising result,' says Dr. Murai.
'Previous to our work, no-one had identified a role for this regulator in the brain.
'Our findings have provided fundamental knowledge about how the brain processes information.
When FXR1P was selectively removed from certain parts of the brain, these new molecules were produced that strengthened connections between brain cells and this correlated with improved memory and recall in the mice.
'We've identified a new pathway that directly regulates how information is handled and this could have relevance for understanding and treating brain diseases.'
'Future research in this area could be very interesting,' he adds.
'If we can identify compounds that control the braking potential of FXR1P, we may be able to alter the amount of brain activity or plasticity.
'For example, in autism, one may want to decrease certain brain activity and in Alzheimer's disease, we may want to enhance the activity.
'By manipulating FXR1P, we may eventually be able to adjust memory formation and retrieval, thus improving the quality of life of people suffering from brain diseases.'
